Mrpl58 | mitochondrial ribosomal protein L58
Physiological systems
20 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Embryo Growth/size/body region Hematopoietic system Skeleton Mortality/aging
15 No significant impact
4 Not tested
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues
| decreased bone mineral density | 1 supporting dataset | Mrpl58tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 8.8x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Mrpl58tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| decreased hematocrit | 1 supporting dataset | Mrpl58tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 3.71x10-13 | ||
| abnormal embryo size | 1 supporting dataset | Mrpl58tm1b(EUCOMM)Hmgu | homozygote | E15.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Mrpl58tm1b(EUCOMM)Hmgu | homozygote | E18.5 | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Mrpl58tm1b(EUCOMM)Hmgu | homozygote | E12.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Mrpl58tm1b(EUCOMM)Hmgu | homozygote | E12.5 | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Mrpl58tm1b(EUCOMM)Hmgu | homozygote | E15.5 | N/A * |
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| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | Section images | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Mrpl58 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Mrpl58.
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| Mrpl58tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Mrpl58tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Mrpl58tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Mrpl58tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |