Ctnnbip1 | catenin beta interacting protein 1
Physiological systems
18 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Growth/size/body region Hematopoietic system Mortality/aging Cardiovascular system
14 No significant impact
6 Not tested
Gene metrics:3Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| thrombocytosis | 1 supporting dataset | Ctnnbip1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.19x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Ctnnbip1tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| enlarged heart | 1 supporting dataset | Ctnnbip1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Ctnnbip1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ctnnbip1.
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| Ctnnbip1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ctnnbip1tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ctnnbip1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Ctnnbip1tm577(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |