Nsmce2 | NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase
Physiological systems
20 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Embryo Growth/size/body region Nervous system Mortality/aging Craniofacial
15 No significant impact
4 Not tested
Data collections
Gene metrics:9Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 3 supporting datasets | Nsmce2em1(IMPC)Bay | homozygote | Early adult | N/A * | ||
| abnormal pharyngeal arch morphology | 1 supporting dataset | Nsmce2em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Nsmce2em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Nsmce2em1(IMPC)Bay | heterozygote | E9.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Nsmce2em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Nsmce2em1(IMPC)Bay | heterozygote | E9.5 | N/A * | ||
| abnormal forebrain development | 1 supporting dataset | Nsmce2em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal embryo turning | 1 supporting dataset | Nsmce2em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Nsmce2em1(IMPC)Bay | homozygote | E12.5 | N/A * | ||
| abnormal embryo turning | 1 supporting dataset | Nsmce2em1(IMPC)Bay | heterozygote | E9.5 | N/A * |
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External links
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| Nsmce2em1(IMPC)Bay | Exon Deletion | | mouse |
| Nsmce2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Nsmce2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |