Ndufa8 | NADH:ubiquinone oxidoreductase subunit A8

GeneMGI:1915625Synonyms: 0610033L03Rik

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Behavior/neurological Skeleton Cardiovascular system Mortality/aging

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Ndufa8^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased total retina thickness	2 supporting datasets	Ndufa8^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.49x10^-5
prolonged RR interval	1 supporting dataset	Ndufa8^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	9.55x10^-14
abnormal retina blood vessel morphology	1 supporting dataset	Ndufa8^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	4.59x10^-5
decreased circulating sodium level	1 supporting dataset	Ndufa8^{tm1a(EUCOMM)Hmgu}	heterozygote	Early adult	3.99x10^-6
cataract	1 supporting dataset	Ndufa8^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.74x10^-5
increased bone mineral content	1 supporting dataset	Ndufa8^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	9.11x10^-5
increased grip strength	2 supporting datasets	Ndufa8^{tm1a(EUCOMM)Hmgu}	heterozygote	Early adult	1.67x10^-5
increased heart rate variability	1 supporting dataset	Ndufa8^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.57x10^-20
abnormal lens morphology	1 supporting dataset	Ndufa8^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.64x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ndufa8.

Associated images

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Histopathology

There is no histopathology data found for Ndufa8.

IMPC related publications

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External links

No external links available for Ndufa8.

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*Ndufa8^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Ndufa8^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ndufa8^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ndufa8^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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