Stt3b | STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
Physiological systems
18 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Hematopoietic system Behavior/neurological Mortality/aging
12 No significant impact
6 Not tested
Data collections
Gene metrics:9Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased locomotor activity | 1 supporting dataset | Stt3bem1(IMPC)J | heterozygote | Early adult | 2.17x10-7 | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Stt3bem1(IMPC)J | homozygote | E12.5 | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Stt3bem1(IMPC)J | homozygote | E9.5 | N/A * | ||
| decreased exploration in new environment | 1 supporting dataset | Stt3bem1(IMPC)J | heterozygote | Early adult | 6.12x10-5 | ||
| decreased mean corpuscular hemoglobin | 1 supporting dataset | Stt3bem1(IMPC)J | heterozygote | Early adult | 4.82x10-9 | ||
| increased circulating cholesterol level | 1 supporting dataset | Stt3bem1(IMPC)J | heterozygote | Early adult | 5.06x10-5 | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Stt3bem1(IMPC)J | heterozygote | Early adult | 3.56x10-6 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Stt3bem1(IMPC)J | homozygote | Early adult | N/A * | ||
| increased circulating bilirubin level | 1 supporting dataset | Stt3bem1(IMPC)J | heterozygote | Early adult | 4.33x10-12 |
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Human diseases caused by Stt3b mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Stt3b.
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| Stt3bem1(IMPC)J | Exon Deletion | | mouse |
| Stt3btm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Stt3btm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |