Ddx39a | DEAD box helicase 39a

GeneMGI:1915528Synonyms: 2610307C23Rik, Ddx39, +1 more

Physiological systems

21 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Integument Embryo Growth/size/body region Nervous system Cardiovascular system Mortality/aging

14 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:51Adult tissues

62Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, complete penetrance	1 supporting dataset	Ddx39a^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal embryo size	1 supporting dataset	Ddx39a^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
preweaning lethality, incomplete penetrance	2 supporting datasets	Ddx39a^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased prepulse inhibition	1 supporting dataset	Ddx39a^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.32x10^-7
abnormal embryo size	1 supporting dataset	Ddx39a^{tm1b(KOMP)Wtsi}	homozygote	E18.5	N/A ^*
abnormal placenta morphology	1 supporting dataset	Ddx39a^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
abnormal skin coloration	1 supporting dataset	Ddx39a^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.1x10^-5
abnormal placenta size	1 supporting dataset	Ddx39a^{tm1b(KOMP)Wtsi}	homozygote	E18.5	N/A ^*
abnormal placenta vasculature	1 supporting dataset	Ddx39a^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
increased circulating phosphate level	1 supporting dataset	Ddx39a^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.54x10^-11

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ddx39a.

Associated images

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Histopathology

There is no histopathology data found for Ddx39a.

IMPC related publications

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External links

No external links available for Ddx39a.

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*Ddx39a^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ddx39a^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ddx39a^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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