Mturn | maturin, neural progenitor differentiation regulator homolog (Xenopus)
Physiological systems
21 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Integument Adipose tissue Growth/size/body region Skeleton
17 No significant impact
3 Not tested
Data collections
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| decreased total body fat amount | 1 supporting dataset | Mturntm1.1(KOMP)Vlcg | homozygote | Early adult | 8.41x10-13 | ||
| increased lean body mass | 1 supporting dataset | Mturntm1.1(KOMP)Vlcg | homozygote | Early adult | 1.01x10-10 | ||
| increased bone mineral content | 1 supporting dataset | Mturntm1.1(KOMP)Vlcg | homozygote | Early adult | 1.16x10-9 | ||
| increased bone mineral density | 1 supporting dataset | Mturntm1.1(KOMP)Vlcg | homozygote | Early adult | 3.24x10-5 | ||
| abnormal coat/ hair morphology | 1 supporting dataset | Mturntm1.1(KOMP)Vlcg | homozygote | Early adult | 3.32x10-7 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/4) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/4) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 0% (0/4) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/4) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 25% (1/4) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/4) | 0.56% (3/532) |
Human diseases caused by Mturn mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Mturn.
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