Cops8 | COP9 signalosome subunit 8
Physiological systems
22 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Immune system Endocrine/exocrine gland Growth/size/body region Hematopoietic system Cardiovascular system Mortality/aging
16 No significant impact
2 Not tested
Data collections
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| enlarged heart | 1 supporting dataset | Cops8em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Cops8em1(IMPC)Ccpcz | homozygote | E12.5 | N/A * | ||
| abnormal spleen morphology | 1 supporting dataset | Cops8em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| abnormal heart morphology | 1 supporting dataset | Cops8em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| abnormal thymus morphology | 1 supporting dataset | Cops8em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| enlarged thymus | 1 supporting dataset | Cops8em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Cops8em1(IMPC)Ccpcz | homozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Cops8em1(IMPC)Ccpcz | homozygote | Early adult | N/A * |
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Human diseases caused by Cops8 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Cops8.
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| Cops8em1(IMPC)Ccpcz | Exon Deletion | | mouse |
| Cops8tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Cops8tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |