Cibar1 | CBY1 interacting BAR domain containing 1
Physiological systems
18 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Limbs/digits/tail Hematopoietic system Skeleton
11 No significant impact
6 Not tested
Data collections
Gene metrics:11Significant phenotypes
2Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| decreased circulating glycerol level | 1 supporting dataset | Cibar1tm1b(KOMP)Wtsi | homozygote | Early adult | 3.67x10-5 | ||
| decreased total body fat amount | 1 supporting dataset | Cibar1tm1b(KOMP)Wtsi | homozygote | Early adult | 1.93x10-6 | ||
| abnormal humerus morphology | 1 supporting dataset | Cibar1tm1b(KOMP)Wtsi | homozygote | Early adult | 8.54x10-10 | ||
| decreased hematocrit | 1 supporting dataset | Cibar1tm1b(KOMP)Wtsi | homozygote | Early adult | 6.91x10-5 | ||
| decreased leukocyte cell number | 1 supporting dataset | Cibar1tm1b(KOMP)Wtsi | homozygote | Early adult | 8.63x10-9 | ||
| improved glucose tolerance | 1 supporting dataset | Cibar1tm1b(KOMP)Wtsi | homozygote | Early adult | 2.56x10-6 | ||
| increased circulating amylase level | 1 supporting dataset | Cibar1tm1b(KOMP)Wtsi | homozygote | Early adult | 5.67x10-5 | ||
| decreased hemoglobin content | 1 supporting dataset | Cibar1tm1b(KOMP)Wtsi | homozygote | Early adult | 4.6x10-5 | ||
| increased lean body mass | 1 supporting dataset | Cibar1tm1b(KOMP)Wtsi | homozygote | Early adult | 1.53x10-6 | ||
| decreased erythrocyte cell number | 1 supporting dataset | Cibar1tm1b(KOMP)Wtsi | homozygote | Early adult | 5.33x10-6 |
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| adrenal gland | heterozygote | n/a | 0% (0/1) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/1) | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/1) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/1) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (1/1) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/1) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/1) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/1) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (1/1) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/1) | 0.41% (2/491) |
Human diseases caused by Cibar1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Cibar1.
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| Cibar1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Cibar1tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |