Rtraf | RNA transcription, translation and transport factor

GeneMGI:1915295Synonyms: 2700060E02Rik

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Immune system Hematopoietic system Behavior/neurological Mortality/aging

15 No significant impact

5 Not tested

Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
21Embryo tissues

Phenotypes

increased eosinophil cell number2 supporting datasetsRtraftm1b(EUCOMM)HmguheterozygoteEarly adult1.02x10-5 
decreased exploration in new environment1 supporting datasetRtraftm1b(EUCOMM)HmguheterozygoteEarly adult7.43x10-5 
preweaning lethality, complete penetrance1 supporting datasetRtraftm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
embryonic lethality prior to tooth bud stage1 supporting datasetRtraftm1b(EUCOMM)HmguhomozygoteE12.5N/A * 
tremors1 supporting datasetRtraftm1b(EUCOMM)HmguheterozygoteEarly adult2.4x10-15 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Rtraftm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Rtraftm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Rtraftm2e(EUCOMM)HmguTargeted, non-conditional allelees cell

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