Emc4 | ER membrane protein complex subunit 4

GeneMGI:1915282Synonyms: Tmem85, 2610318K02Rik

Physiological systems

18 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Pigmentation Integument Hematopoietic system Cardiovascular system Mortality/aging

11 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Emc4^{tm1(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased eosinophil cell number	2 supporting datasets	Emc4^{tm1(KOMP)Wtsi}	heterozygote	Early adult	5.66x10^-15
increased basophil cell number	2 supporting datasets	Emc4^{tm1(KOMP)Wtsi}	heterozygote	Early adult	4.31x10^-23
decreased heart left ventricle size	1 supporting dataset	Emc4^{tm1(KOMP)Wtsi}	heterozygote	Early adult	8.24x10^-5
increased fasting circulating glucose level	1 supporting dataset	Emc4^{tm1(KOMP)Wtsi}	heterozygote	Early adult	3.18x10^-5
abnormal coat/hair pigmentation	1 supporting dataset	Emc4^{tm1(KOMP)Wtsi}	heterozygote	Early adult	1.6x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Emc4.

Associated images

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Histopathology

There is no histopathology data found for Emc4.

IMPC related publications

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External links

No external links available for Emc4.

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*Emc4^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Emc4^{tm1(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell mouse
*Emc4^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

My Genes