Retreg3 | reticulophagy regulator family member 3
Physiological systems
22 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Pigmentation Growth/size/body region Nervous system Vision/eye Hematopoietic system
16 No significant impact
2 Not tested
Data collections
Gene metrics:14Significant phenotypes
0Associated diseases
Expression examined in:50Adult tissues
42Embryo tissues
| increased blood urea nitrogen level | 1 supporting dataset | Retreg3tm2a(EUCOMM)Wtsi | homozygote | Early adult | 1.82x10-5 | ||
| abnormal retina pigmentation | 2 supporting datasets | Retreg3tm2a(EUCOMM)Wtsi | homozygote | Early adult | 5.34x10-6 | ||
| abnormal eye morphology | 1 supporting dataset | Retreg3tm2a(EUCOMM)Wtsi | homozygote | Early adult | 9.43x10-6 | ||
| decreased prepulse inhibition | 4 supporting datasets | Retreg3tm2b(EUCOMM)Wtsi | homozygote | Early adult | 1.11x10-9 | ||
| increased blood urea nitrogen level | 1 supporting dataset | Retreg3tm2b(EUCOMM)Wtsi | homozygote | Early adult | 1.28x10-5 | ||
| abnormal retina morphology | 1 supporting dataset | Retreg3tm2b(EUCOMM)Wtsi | homozygote | Early adult | 1.46x10-6 | ||
| increased lean body mass | 1 supporting dataset | Retreg3tm2b(EUCOMM)Wtsi | homozygote | Early adult | 1.84x10-5 | ||
| abnormal retina morphology | 2 supporting datasets | Retreg3tm2a(EUCOMM)Wtsi | homozygote | Early adult | 5.34x10-6 | ||
| increased circulating amylase level | 1 supporting dataset | Retreg3tm2b(EUCOMM)Wtsi | homozygote | Early adult | 5.98x10-11 | ||
| decreased mean corpuscular hemoglobin concentration | 1 supporting dataset | Retreg3tm2a(EUCOMM)Wtsi | homozygote | Early adult | 7.79x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/4) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/4) | 0% (0/394) |
| brain | heterozygote | n/a | 0% (0/4) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/4) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/4) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
Human diseases caused by Retreg3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Retreg3.
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| Retreg3tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Retreg3tm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Retreg3tm2b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Retreg3tm2e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Retreg3tm3a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Retreg3tm95(pL1L2_GT2_DelLacZ_bsd) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |