U2surp | U2 snRNP-associated SURP domain containing
Physiological systems
18 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Hematopoietic system Behavior/neurological Skeleton Mortality/aging
13 No significant impact
6 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 1 supporting dataset | U2surpem1(IMPC)J | homozygote | Early adult | N/A * | ||
| decreased locomotor activity | 4 supporting datasets | U2surpem1(IMPC)J | heterozygote | Early adult | 1.58x10-5 | ||
| decreased circulating glucose level | 1 supporting dataset | U2surpem1(IMPC)J | heterozygote | Early adult | 2.14x10-7 | ||
| increased hematocrit | 1 supporting dataset | U2surpem1(IMPC)J | heterozygote | Early adult | 3.16x10-6 | ||
| decreased bone mineral density | 1 supporting dataset | U2surpem1(IMPC)J | heterozygote | Early adult | 5.05x10-6 | ||
| increased erythrocyte cell number | 1 supporting dataset | U2surpem1(IMPC)J | heterozygote | Early adult | 9.97x10-5 |
| | | | | | | | | | |
Human diseases caused by U2surp mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for U2surp.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| U2surpem1(IMPC)J | Exon Deletion | | mouse |
| U2surptm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| U2surptm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |