Atp5mc2 | ATP synthase membrane subunit c locus 2
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Vision/eye Mortality/aging Cardiovascular system
15 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal retina morphology | 1 supporting dataset | Atp5mc2tm2b(EUCOMM)Hmgu | heterozygote | Early adult | 8.07x10-6 | ||
| abnormal lens morphology | 2 supporting datasets | Atp5mc2tm2b(EUCOMM)Hmgu | heterozygote | Early adult | 3.5x10-8 | ||
| decreased total retina thickness | 1 supporting dataset | Atp5mc2tm2b(EUCOMM)Hmgu | heterozygote | Early adult | 2.74x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Atp5mc2tm2b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| abnormal retina vasculature morphology | 1 supporting dataset | Atp5mc2tm2b(EUCOMM)Hmgu | heterozygote | Early adult | 8.32x10-6 | ||
| abnormal retina blood vessel morphology | 1 supporting dataset | Atp5mc2tm2b(EUCOMM)Hmgu | heterozygote | Early adult | 4.03x10-6 | ||
| increased fasting circulating glucose level | 1 supporting dataset | Atp5mc2tm2b(EUCOMM)Hmgu | heterozygote | Early adult | 9.19x10-5 |
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Human diseases caused by Atp5mc2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Atp5mc2.
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| Atp5mc2tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Atp5mc2tm2b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |