Ube2f | ubiquitin-conjugating enzyme E2F (putative)

GeneMGI:1915171Synonyms: 2510010F15Rik

Physiological systems

22 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Embryo Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Liver/biliary system Cardiovascular system Mortality/aging Craniofacial

13 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal neural tube morphology	1 supporting dataset	Ube2f^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Ube2f^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal heart morphology	1 supporting dataset	Ube2f^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
abnormal pharyngeal arch morphology	1 supporting dataset	Ube2f^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
increased heart weight	2 supporting datasets	Ube2f^em1(IMPC)Mbp	heterozygote	Early adult	5.02x10^-7
abnormal pericardium morphology	1 supporting dataset	Ube2f^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
abnormal heart shape	1 supporting dataset	Ube2f^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal liver morphology	1 supporting dataset	Ube2f^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal limb bud morphology	1 supporting dataset	Ube2f^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
prenatal lethality prior to heart atrial septation	1 supporting dataset	Ube2f^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ube2f.

Associated images

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Histopathology

There is no histopathology data found for Ube2f.

IMPC related publications

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External links

No external links available for Ube2f.

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*Ube2f^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Ube2f^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Ube2f^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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