Chd8 | chromodomain helicase DNA binding protein 8
Physiological systems
20 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Hematopoietic system Behavior/neurological Mortality/aging
15 No significant impact
4 Not tested
Data collections
Gene metrics:9Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| impaired glucose tolerance | 1 supporting dataset | Chd8em1(IMPC)Mbp | heterozygote | Early adult | 1.93x10-5 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Chd8em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal spleen morphology | 1 supporting dataset | Chd8em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| decreased locomotor activity | 2 supporting datasets | Chd8em1(IMPC)Mbp | heterozygote | Early adult | 9.86x10-7 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Chd8em1(IMPC)Mbp | homozygote | E9.5 | N/A * | ||
| enlarged lymph nodes | 1 supporting dataset | Chd8em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| increased lymphocyte cell number | 1 supporting dataset | Chd8em1(IMPC)Mbp | heterozygote | Early adult | 7.96x10-5 |
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Human diseases caused by Chd8 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Chd8.
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| Chd8em1(IMPC)Mbp | Exon Deletion | | mouse |
| Chd8tm49072(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |