Chd8 | chromodomain helicase DNA binding protein 8
Physiological systems
20 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Hematopoietic system Behavior/neurological Mortality/aging
15 No significant impact
4 Not tested
Data collections
Gene metrics:9Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| impaired glucose tolerance | 1 supporting dataset | Chd8em1(IMPC)Mbp | heterozygote | Early adult | 1.93x10-5 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Chd8em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal spleen morphology | 1 supporting dataset | Chd8em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| decreased locomotor activity | 2 supporting datasets | Chd8em1(IMPC)Mbp | heterozygote | Early adult | 9.86x10-7 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Chd8em1(IMPC)Mbp | homozygote | E9.5 | N/A * | ||
| enlarged lymph nodes | 1 supporting dataset | Chd8em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| increased lymphocyte cell number | 1 supporting dataset | Chd8em1(IMPC)Mbp | heterozygote | Early adult | 7.96x10-5 |
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External links
No external links available for Chd8.
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| Chd8em1(IMPC)Mbp | Exon Deletion | | mouse |
| Chd8tm49072(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |