Wfdc2 | WAP four-disulfide core domain 2

GeneMGI:1914951Synonyms: WAP5, 1600023A02Rik, +1 more

Physiological systems

16 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Mortality/aging Cardiovascular system

10 No significant impact

8 Not tested

Gene metrics:4Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased circulating amylase level1 supporting datasetWfdc2em1(IMPC)HheterozygoteEarly adult1.39x10-7 
preweaning lethality, incomplete penetrance1 supporting datasetWfdc2em1(IMPC)HhomozygoteEarly adultN/A * 
enlarged heart1 supporting datasetWfdc2em1(IMPC)HheterozygoteEarly adultN/A * 
decreased eosinophil cell number1 supporting datasetWfdc2em1(IMPC)HheterozygoteEarly adult7.62x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Wfdc2em1(IMPC)HExon Deletionmouse
Wfdc2tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
Wfdc2tm1e(EUCOMM)HmguTargeted, non-conditional allelees cell

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