Cog6 | component of oligomeric golgi complex 6

GeneMGI:1914792

Physiological systems

18 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Pigmentation Integument Vision/eye Hematopoietic system Skeleton

11 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:58Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased memory-marker CD4-positive NK T cell number	4 supporting datasets	Cog6^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number	4 supporting datasets	Cog6^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased KLRG1+ CD4 alpha-beta T cell number	2 supporting datasets	Cog6^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased CD4-positive NK T cell number	2 supporting datasets	Cog6^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased NK cell number	5 supporting datasets	Cog6^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased NK T cell number	6 supporting datasets	Cog6^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased mean platelet volume	1 supporting dataset	Cog6^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6.23x10^-6
increased CD4-negative NK T cell number	1 supporting dataset	Cog6^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased Ly6C-positive mature NK cell number	2 supporting datasets	Cog6^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased alpha-beta T cell number	6 supporting datasets	Cog6^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cog6.

Associated images

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Histopathology

There is no histopathology data found for Cog6.

IMPC related publications

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External links

No external links available for Cog6.

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*Cog6^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Cog6^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse

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