Ttll4 | tubulin tyrosine ligase-like family, member 4

GeneMGI:1914784Synonyms: 4632407P03Rik

Physiological systems

20 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Skeleton

17 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased circulating alanine transaminase level	1 supporting dataset	Ttll4^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6.11x10^-6
abnormal retina morphology	2 supporting datasets	Ttll4^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.51x10^-6
increased bone mineral content	1 supporting dataset	Ttll4^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.17x10^-5
increased circulating LDL cholesterol level	1 supporting dataset	Ttll4^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.24x10^-7
increased circulating HDL cholesterol level	1 supporting dataset	Ttll4^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	8.6x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ttll4.

Associated images

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Histopathology

There is no histopathology data found for Ttll4.

IMPC related publications

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External links

No external links available for Ttll4.

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*Ttll4^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Ttll4^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ttll4^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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