Mettl16 | methyltransferase 16, N6-methyladenosine

GeneMGI:1914743Synonyms: Mett10d, 2810013M15Rik, +2 more

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Pigmentation Integument Hematopoietic system Mortality/aging Renal/urinary system

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

25Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased urine creatinine level	1 supporting dataset	Mettl16^{tm1b(KOMP)Mbp}	heterozygote	Early adult	9.19x10^-5
embryonic lethality prior to tooth bud stage	1 supporting dataset	Mettl16^{tm1b(KOMP)Mbp}	homozygote	E12.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Mettl16^{tm1b(KOMP)Mbp}	homozygote	Early adult	N/A ^*
abnormal coat/hair pigmentation	2 supporting datasets	Mettl16^{tm1b(KOMP)Mbp}	heterozygote	Early adult	4.12x10^-6
increased circulating HDL cholesterol level	1 supporting dataset	Mettl16^{tm1b(KOMP)Mbp}	heterozygote	Early adult	4.96x10^-6
decreased erythrocyte cell number	1 supporting dataset	Mettl16^{tm1b(KOMP)Mbp}	heterozygote	Early adult	2.16x10^-5
embryonic lethality prior to organogenesis	1 supporting dataset	Mettl16^{tm1b(KOMP)Mbp}	homozygote	E9.5	N/A ^*
increased circulating cholesterol level	1 supporting dataset	Mettl16^{tm1b(KOMP)Mbp}	heterozygote	Early adult	1.63x10^-6
decreased hematocrit	1 supporting dataset	Mettl16^{tm1b(KOMP)Mbp}	heterozygote	Early adult	2.67x10^-6
decreased hemoglobin content	1 supporting dataset	Mettl16^{tm1b(KOMP)Mbp}	heterozygote	Early adult	6.5x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mettl16.

Associated images

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Histopathology

There is no histopathology data found for Mettl16.

IMPC related publications

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External links

No external links available for Mettl16.

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*Mettl16^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Mettl16^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Mettl16^{tm1b(KOMP)Mbp}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Mettl16^{tm1e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	ES Cell

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