Dhx40 | DEAH-box helicase 40
Physiological systems
20 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Immune system Adipose tissue Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system
12 No significant impact
4 Not tested
Data collections
Gene metrics:19Significant phenotypes
0Associated diseases
Expression examined in:49Adult tissues
0Embryo tissues
| increased total body fat amount | 1 supporting dataset | Dhx40tm1(NCOM)Cmhd | homozygote | Early adult | 5.11x10-8 | ||
| decreased hematocrit | 1 supporting dataset | Dhx40tm1b(KOMP)Wtsi | homozygote | Early adult | 6.17x10-10 | ||
| decreased hemoglobin content | 1 supporting dataset | Dhx40tm1b(KOMP)Wtsi | homozygote | Early adult | 1.67x10-14 | ||
| decreased total retina thickness | 1 supporting dataset | Dhx40tm1b(KOMP)Wtsi | homozygote | Early adult | 9.39x10-7 | ||
| increased spleen weight | 1 supporting dataset | Dhx40tm1b(KOMP)Wtsi | homozygote | Early adult | 7.04x10-5 | ||
| decreased locomotor activity | 1 supporting dataset | Dhx40tm1(NCOM)Cmhd | homozygote | Early adult | 9.94x10-5 | ||
| abnormal retina blood vessel morphology | 1 supporting dataset | Dhx40tm1b(KOMP)Wtsi | homozygote | Early adult | 9.65x10-6 | ||
| abnormal bone mineralization | 1 supporting dataset | Dhx40tm1(NCOM)Cmhd | homozygote | Early adult | 3.6x10-6 | ||
| increased lean body mass | 1 supporting dataset | Dhx40tm1b(KOMP)Wtsi | homozygote | Early adult | 1.82x10-5 | ||
| abnormal cornea morphology | 1 supporting dataset | Dhx40tm1b(KOMP)Wtsi | homozygote | Early adult | 4.28x10-5 |
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| adrenal gland | heterozygote | Wholemount images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Wholemount images | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | Wholemount images | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Wholemount images | 100% (2/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Wholemount images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/491) |
Human diseases caused by Dhx40 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Dhx40.
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| Dhx40tm1(NCOM)Cmhd | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Dhx40tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Dhx40tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Dhx40tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |