Dhx40 | DEAH-box helicase 40

GeneMGI:1914737Synonyms: ARG147, DDX40, +1 more

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Immune system Adipose tissue Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

12 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:19Significant phenotypes

0Associated diseases

Expression examined in:49Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:



increased total body fat amount	1 supporting dataset	Dhx40^{tm1(NCOM)Cmhd}	homozygote	Early adult	5.11x10^-8
decreased hematocrit	1 supporting dataset	Dhx40^{tm1b(KOMP)Wtsi}	homozygote	Early adult	6.17x10^-10
decreased hemoglobin content	1 supporting dataset	Dhx40^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.67x10^-14
decreased total retina thickness	1 supporting dataset	Dhx40^{tm1b(KOMP)Wtsi}	homozygote	Early adult	9.39x10^-7
increased spleen weight	1 supporting dataset	Dhx40^{tm1b(KOMP)Wtsi}	homozygote	Early adult	7.04x10^-5
decreased locomotor activity	1 supporting dataset	Dhx40^{tm1(NCOM)Cmhd}	homozygote	Early adult	9.94x10^-5
abnormal retina blood vessel morphology	1 supporting dataset	Dhx40^{tm1b(KOMP)Wtsi}	homozygote	Early adult	9.65x10^-6
abnormal bone mineralization	1 supporting dataset	Dhx40^{tm1(NCOM)Cmhd}	homozygote	Early adult	3.6x10^-6
increased lean body mass	1 supporting dataset	Dhx40^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.82x10^-5
abnormal cornea morphology	1 supporting dataset	Dhx40^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.28x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dhx40.

Associated images

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Histopathology

There is no histopathology data found for Dhx40.

IMPC related publications

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External links

No external links available for Dhx40.

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*Dhx40^{tm1(NCOM)Cmhd}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector es cell
*Dhx40^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Dhx40^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Dhx40^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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