Slc47a1 | solute carrier family 47, member 1
Physiological systems
18 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Homeostasis/metabolism Behavior/neurological
16 No significant impact
6 Not tested
Data collections
Gene metrics:3Significant phenotypes
0Associated diseases
Expression examined in:70Adult tissues
0Embryo tissues
| abnormal vocalization | 1 supporting dataset | Slc47a1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.1x10-5 | ||
| decreased circulating phosphate level | 1 supporting dataset | Slc47a1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 4.74x10-5 | ||
| increased circulating total protein level | 1 supporting dataset | Slc47a1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 5.59x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
Human diseases caused by Slc47a1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Slc47a1.
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| Slc47a1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Slc47a1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Slc47a1tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Slc47a1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Slc47a1tm33798(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |