Mtpap | mitochondrial poly(A) polymerase

GeneMGI:1914690Synonyms: Papd1, Tent6, +1 more

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system Behavior/neurological Mortality/aging

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

29Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



hyperactivity	1 supporting dataset	Mtpap^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	4.14x10^-5
preweaning lethality, complete penetrance	2 supporting datasets	Mtpap^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
abnormal locomotor behavior	1 supporting dataset	Mtpap^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	5.11x10^-6
decreased circulating creatinine level	1 supporting dataset	Mtpap^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	4.05x10^-5
embryonic lethality prior to tooth bud stage	1 supporting dataset	Mtpap^{tm1.1(KOMP)Vlcg}	homozygote	E12.5	N/A ^*
increased erythrocyte cell number	1 supporting dataset	Mtpap^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	6.42x10^-5
embryonic lethality prior to organogenesis	1 supporting dataset	Mtpap^{tm1.1(KOMP)Vlcg}	homozygote	E9.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mtpap.

Associated images

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Histopathology

There is no histopathology data found for Mtpap.

IMPC related publications

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External links

No external links available for Mtpap.

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*Mtpap^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Mtpap^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Mtpap^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Mtpap^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Mtpap^{tm80438(L1L2_Pgk_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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