Mrm3 | mitochondrial rRNA methyltransferase 3

GeneMGI:1914640Synonyms: 4833420N02Rik, HC90, +1 more

Physiological systems

20 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Skeleton Mortality/aging

17 No significant impact

4 Not tested

Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues

Phenotypes

embryonic lethality prior to tooth bud stage1 supporting datasetMrm3tm1.1(KOMP)VlcghomozygoteE12.5N/A * 
preweaning lethality, complete penetrance1 supporting datasetMrm3tm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
embryonic lethality prior to organogenesis1 supporting datasetMrm3tm1.1(KOMP)VlcghomozygoteE9.5N/A * 
decreased circulating glucose level1 supporting datasetMrm3tm1.1(KOMP)VlcgheterozygoteEarly adult1.15x10-5 
abnormal bone structure1 supporting datasetMrm3tm1.1(KOMP)VlcgheterozygoteEarly adult5.43x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Mrm3tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Mrm3tm1(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell
Mrm3tm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse
Mrm3tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell

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