Brd3 | bromodomain containing 3
Physiological systems
17 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Pigmentation Integument Behavior/neurological Cardiovascular system Mortality/aging
12 No significant impact
7 Not tested
Data collections
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| prolonged RR interval | 1 supporting dataset | Brd3em1(IMPC)J | homozygote | Early adult | 3.67x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Brd3em1(IMPC)J | homozygote | Early adult | N/A * | ||
| increased grip strength | 1 supporting dataset | Brd3em1(IMPC)J | homozygote | Early adult | 1.06x10-5 | ||
| abnormal coat/hair pigmentation | 1 supporting dataset | Brd3em1(IMPC)J | homozygote | Early adult | 3.85x10-5 | ||
| decreased locomotor activity | 1 supporting dataset | Brd3em1(IMPC)J | homozygote | Early adult | 4.17x10-5 |
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Human diseases caused by Brd3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Brd3.
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| Brd3em1(IMPC)J | Exon Deletion | | mouse |
| Brd3tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Brd3tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Brd3tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Brd3tm2e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Brd3tm34188(L1L2_gt2) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Brd3tm3a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Brd3tm3e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |