Cap2 | cyclase associated actin cytoskeleton regulatory protein 2

GeneMGI:1914502Synonyms: 2810452G09Rik

Physiological systems

22 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system Mortality/aging

16 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



cataract	1 supporting dataset	Cap2^{tm1e(EUCOMM)Wtsi}	heterozygote	Early adult	6.07x10^-7
prolonged ST segment	1 supporting dataset	Cap2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.56x10^-6
abnormal locomotor activation	1 supporting dataset	Cap2^{tm1e(EUCOMM)Wtsi}	heterozygote	Early adult	1.17x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Cap2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased circulating triglyceride level	1 supporting dataset	Cap2^{tm1e(EUCOMM)Wtsi}	homozygote	Early adult	5.51x10^-5
prolonged QT interval	1 supporting dataset	Cap2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.19x10^-5
increased red blood cell distribution width	1 supporting dataset	Cap2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.98x10^-7
decreased mean corpuscular hemoglobin	1 supporting dataset	Cap2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	3.71x10^-14
prolonged RR interval	1 supporting dataset	Cap2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	9.51x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cap2.

Associated images

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Histopathology

There is no histopathology data found for Cap2.

IMPC related publications

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External links

No external links available for Cap2.

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*Cap2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Cap2^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Cap2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	mouse

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