Ccdc25 | coiled-coil domain containing 25
Physiological systems
22 / 24 physiological systems tested
11 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Embryo Growth/size/body region Nervous system Vision/eye Liver/biliary system Hematopoietic system Behavior/neurological Cardiovascular system Mortality/aging
11 No significant impact
2 Not tested
Data collections
Gene metrics:12Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal vitreous body morphology | 1 supporting dataset | Ccdc25em1(IMPC)Mbp | heterozygote | Early adult | 1.63x10-5 | ||
| impaired glucose tolerance | 1 supporting dataset | Ccdc25em1(IMPC)Mbp | heterozygote | Early adult | 5.16x10-8 | ||
| abnormal placenta morphology | 1 supporting dataset | Ccdc25em1(IMPC)Mbp | homozygote | E18.5 | N/A * | ||
| abnormal liver morphology | 1 supporting dataset | Ccdc25em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Ccdc25em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| small spleen | 2 supporting datasets | Ccdc25em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| no spontaneous movement | 1 supporting dataset | Ccdc25em1(IMPC)Mbp | heterozygote | E18.5 | N/A * | ||
| cataract | 1 supporting dataset | Ccdc25em1(IMPC)Mbp | heterozygote | Early adult | 1.36x10-5 | ||
| enlarged heart | 1 supporting dataset | Ccdc25em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| abnormal retina morphology | 1 supporting dataset | Ccdc25em1(IMPC)Mbp | heterozygote | Early adult | 5.03x10-5 |
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Human diseases caused by Ccdc25 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Ccdc25.
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| Ccdc25em1(IMPC)Mbp | Exon Deletion | | mouse |
| Ccdc25tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Ccdc25tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Ccdc25tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Ccdc25tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |