Fbxo5 | F-box protein 5

GeneMGI:1914391Synonyms: 2510044I10Rik, Emi1, +1 more

Physiological systems

21 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Integument Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Mortality/aging Renal/urinary system

14 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



embryonic lethality prior to organogenesis	1 supporting dataset	Fbxo5^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
abnormal kidney morphology	1 supporting dataset	Fbxo5^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal eye morphology	2 supporting datasets	Fbxo5^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Fbxo5^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
cataract	1 supporting dataset	Fbxo5^em1(IMPC)Mbp	heterozygote	Early adult	5.66x10^-5
increased freezing behavior	1 supporting dataset	Fbxo5^em1(IMPC)Mbp	heterozygote	Early adult	1.89x10^-6
decreased mean corpuscular volume	1 supporting dataset	Fbxo5^em1(IMPC)Mbp	heterozygote	Early adult	4.52x10^-5
abnormal vitreous body morphology	1 supporting dataset	Fbxo5^em1(IMPC)Mbp	heterozygote	Early adult	5.76x10^-5
enlarged kidney	1 supporting dataset	Fbxo5^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal skin morphology	1 supporting dataset	Fbxo5^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Fbxo5.

Associated images

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Histopathology

There is no histopathology data found for Fbxo5.

IMPC related publications

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External links

No external links available for Fbxo5.

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*Fbxo5^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Fbxo5^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Fbxo5^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Fbxo5^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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