Fancl | Fanconi anemia, complementation group L

GeneMGI:1914280Synonyms: B230118H11Rik, Pog, +3 more

Physiological systems

17 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Pigmentation Immune system Integument Adipose tissue Growth/size/body region Hematopoietic system Skeleton

10 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal coat/hair pigmentation	5 supporting datasets	Fancl^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.63x10^-6
increased basophil cell number	2 supporting datasets	Fancl^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.58x10^-10
decreased body length	1 supporting dataset	Fancl^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.7x10^-5
decreased bone mineral content	2 supporting datasets	Fancl^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.97x10^-11
decreased lean body mass	2 supporting datasets	Fancl^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.02x10^-5
abnormal bone structure	1 supporting dataset	Fancl^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.11x10^-9
decreased bone mineral density	1 supporting dataset	Fancl^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.62x10^-9
increased eosinophil cell number	2 supporting datasets	Fancl^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.39x10^-11
increased total body fat amount	1 supporting dataset	Fancl^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.21x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Fancl.

Associated images

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Histopathology

There is no histopathology data found for Fancl.

IMPC related publications

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External links

No external links available for Fancl.

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*Fancl^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Fancl^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Fancl^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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