Cisd2 | CDGSH iron sulfur domain 2

GeneMGI:1914256Synonyms: Miner1, 1500026J14Rik, +4 more

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Vision/eye Behavior/neurological Cardiovascular system

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased circulating triglyceride level	1 supporting dataset	Cisd2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.41x10^-9
abnormal behavior	8 supporting datasets	Cisd2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6.13x10^-11
decreased circulating creatinine level	1 supporting dataset	Cisd2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	7.26x10^-5
abnormal glucose homeostasis	1 supporting dataset	Cisd2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.8x10^-15
decreased circulating amylase level	1 supporting dataset	Cisd2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.52x10^-5
increased circulating aspartate transaminase level	1 supporting dataset	Cisd2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	7.97x10^-6
cornea vascularization	1 supporting dataset	Cisd2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	7.6x10^-5
abnormal eye size	1 supporting dataset	Cisd2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.82x10^-5
increased lean body mass	1 supporting dataset	Cisd2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.06x10^-6
increased circulating phosphate level	1 supporting dataset	Cisd2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.79x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cisd2.

Associated images

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Histopathology

There is no histopathology data found for Cisd2.

IMPC related publications

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External links

No external links available for Cisd2.

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*Cisd2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Cisd2^{tm1c(EUCOMM)Wtsi}*	Wild type floxed exon (post-Flp)	‌	mouse
*Cisd2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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