Rrp8 | ribosomal RNA processing 8
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Behavior/neurological Mortality/aging
14 No significant impact
5 Not tested
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:50Adult tissues
50Embryo tissues
| decreased coping response | 1 supporting dataset | Rrp8tm1.1(KOMP)Vlcg | heterozygote | Early adult | 9.16x10-5 | ||
| abnormal embryo size | 1 supporting dataset | Rrp8tm1.1(KOMP)Vlcg | homozygote | E18.5 | N/A * | ||
| decreased fasting circulating glucose level | 1 supporting dataset | Rrp8tm1.1(KOMP)Vlcg | heterozygote | Early adult | 1.56x10-6 | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Rrp8tm1.1(KOMP)Vlcg | heterozygote | Early adult | 1.77x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Rrp8tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| increased circulating chloride level | 1 supporting dataset | Rrp8tm1.1(KOMP)Vlcg | heterozygote | Early adult | 4.33x10-9 | ||
| embryonic growth retardation | 1 supporting dataset | Rrp8tm1.1(KOMP)Vlcg | homozygote | E18.5 | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (1/1) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | Section images | n/a | 0% (0/394) |
| bone marrow | heterozygote | Section images | 100% (2/2) | 0% (0/22) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
Human diseases caused by Rrp8 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Rrp8.
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| Rrp8tm1(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Rrp8tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Rrp8tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Rrp8tm442403(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |