Med28 | mediator complex subunit 28
Physiological systems
22 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Embryo Growth/size/body region Hearing/vestibular/ear Hematopoietic system Mortality/aging
15 No significant impact
2 Not tested
Data collections
Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
29Embryo tissues
| preweaning lethality, complete penetrance | 3 supporting datasets | Med28tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Med28tm1.1(KOMP)Vlcg | homozygote | E12.5 | N/A * | ||
| small spleen | 1 supporting dataset | Med28tm1.1(KOMP)Vlcg | heterozygote | Early adult | N/A * | ||
| increased respiratory quotient | 1 supporting dataset | Med28tm1.1(KOMP)Vlcg | heterozygote | Early adult | 1.19x10-5 | ||
| decreased circulating serum albumin level | 1 supporting dataset | Med28tm1.1(KOMP)Vlcg | heterozygote | Early adult | 4.52x10-5 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Med28tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| increased body length | 1 supporting dataset | Med28tm1.1(KOMP)Vlcg | heterozygote | Early adult | 3.38x10-30 | ||
| abnormal auditory brainstem response | 1 supporting dataset | Med28tm1.1(KOMP)Vlcg | heterozygote | Early adult | 2.9x10-6 | ||
| abnormal spleen morphology | 1 supporting dataset | Med28tm1.1(KOMP)Vlcg | heterozygote | Early adult | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Med28tm1.1(KOMP)Vlcg | heterozygote | E9.5 | N/A * |
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| adrenal gland | heterozygote | Section images Wholemount images | 75% (3/4) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/4) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | Wholemount images | 100% (4/4) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/4) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | Section images | 75% (3/4) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images Wholemount images | 100% (4/4) | 0.56% (3/532) |
Human diseases caused by Med28 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Med28.
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| Med28tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Med28tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Med28tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Med28tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |