Med28 | mediator complex subunit 28

GeneMGI:1914249Synonyms: 1500003D12Rik, Eg1, +1 more

Physiological systems

22 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Embryo Growth/size/body region Hearing/vestibular/ear Hematopoietic system Mortality/aging

15 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

29Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, complete penetrance	3 supporting datasets	Med28^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
embryonic lethality prior to tooth bud stage	1 supporting dataset	Med28^{tm1.1(KOMP)Vlcg}	homozygote	E12.5	N/A ^*
small spleen	1 supporting dataset	Med28^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
increased respiratory quotient	1 supporting dataset	Med28^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	1.19x10^-5
decreased circulating serum albumin level	1 supporting dataset	Med28^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	4.52x10^-5
embryonic lethality prior to organogenesis	1 supporting dataset	Med28^{tm1.1(KOMP)Vlcg}	homozygote	E9.5	N/A ^*
increased body length	1 supporting dataset	Med28^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	3.38x10^-30
abnormal auditory brainstem response	1 supporting dataset	Med28^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	2.9x10^-6
abnormal spleen morphology	1 supporting dataset	Med28^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
abnormal embryo size	1 supporting dataset	Med28^{tm1.1(KOMP)Vlcg}	heterozygote	E9.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Med28.

Associated images

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Histopathology

There is no histopathology data found for Med28.

IMPC related publications

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External links

No external links available for Med28.

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*Med28^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Med28^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Med28^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Med28^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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