Sdha | succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
Physiological systems
19 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Behavior/neurological Mortality/aging
16 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
8Associated diseases
Expression examined in:49Adult tissues
21Embryo tissues
| decreased circulating glucose level | 1 supporting dataset | Sdhatm2b(KOMP)Wtsi | heterozygote | Early adult | 1.94x10-7 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Sdhatm2b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| abnormal behavior | 1 supporting dataset | Sdhatm2b(KOMP)Wtsi | heterozygote | Early adult | 1.09x10-7 | ||
| increased circulating sodium level | 1 supporting dataset | Sdhatm2b(KOMP)Wtsi | heterozygote | Early adult | 1.15x10-7 | ||
| increased circulating free fatty acids level | 1 supporting dataset | Sdhatm2b(KOMP)Wtsi | heterozygote | Early adult | 1.42x10-6 | ||
| decreased thigmotaxis | 2 supporting datasets | Sdhatm2b(KOMP)Wtsi | heterozygote | Early adult | 1.09x10-7 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Sdhatm2b(KOMP)Wtsi | homozygote | Early adult | N/A * |
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External links
No external links available for Sdha.
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| Sdhatm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Sdhatm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Sdhatm2b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Sdhatm2e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Sdhatm50282(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |