Dnase1l2 | deoxyribonuclease 1-like 2
Physiological systems
23 / 24 physiological systems tested
15 Significantly impacted by the knock-out
Immune system Integument Adipose tissue Growth/size/body region Digestive/alimentary Hematopoietic system Cardiovascular system Craniofacial Homeostasis/metabolism Pigmentation Limbs/digits/tail Nervous system Vision/eye Behavior/neurological Skeleton
8 No significant impact
1 Not tested
Data collections
Gene metrics:48Significant phenotypes
0Associated diseases
Expression examined in:158Adult tissues
58Embryo tissues
| decreased body length | 7 supporting datasets | Dnase1l2tm1.1(KOMP)Wtsi | homozygote | Early adult | 7.91x10-16 | ||
| decreased grip strength | 17 supporting datasets | Dnase1l2tm1.1(KOMP)Wtsi | homozygote | Early adult | 1.46x10-17 | ||
| decreased locomotor activity | 9 supporting datasets | Dnase1l2tm1.1(KOMP)Wtsi | homozygote | Early adult | 3.35x10-6 | ||
| abnormal autopod morphology | 2 supporting datasets | Dnase1l2tm1.1(KOMP)Wtsi | homozygote | Early adult | 6.02x10-5 | ||
| abnormal bone structure | 1 supporting dataset | Dnase1l2tm1(KOMP)Wtsi | homozygote | Early adult | 8.59x10-8 | ||
| abnormal digit morphology | 18 supporting datasets | Dnase1l2tm1.1(KOMP)Wtsi | homozygote | Early adult | 1.37x10-19 | ||
| abnormal digit morphology | 3 supporting datasets | Dnase1l2tm1(KOMP)Wtsi | homozygote | Early adult | 2.45x10-10 | ||
| abnormal optic disk morphology | 2 supporting datasets | Dnase1l2tm1.1(KOMP)Wtsi | homozygote | Early adult | 6.64x10-6 | ||
| persistence of hyaloid vascular system | 2 supporting datasets | Dnase1l2tm1.1(KOMP)Wtsi | homozygote | Early adult | 1.08x10-5 | ||
| abnormal nail morphology | 2 supporting datasets | Dnase1l2tm1.1(KOMP)Wtsi | homozygote | Early adult | 5.66x10-8 |
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| adrenal gland | homozygote | Wholemount images | 0% (0/1) | 0.7% (4/570) |
| adrenal gland | heterozygote | n/a | 0% (0/20) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/17) | 0.19% (1/533) |
| aorta | homozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| blood vessel | heterozygote | n/a | 0% (0/4) | 0% (0/173) |
| bone | homozygote | Wholemount images | 0% (0/1) | 0% (0/394) |
| bone | heterozygote | Wholemount images | 0% (0/9) | 0% (0/394) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | homozygote | n/a | 0% (0/2) | 0.86% (5/579) |
Human diseases caused by Dnase1l2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Dnase1l2.
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| Dnase1l2em1(IMPC)Bay | Exon Deletion | | mouse |
| Dnase1l2em1(IMPC)J | Exon Deletion | | mouse |
| Dnase1l2em2(IMPC)Mbp | Insertion, Intragenic deletion | | mouse |
| Dnase1l2tm1(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell mouse |
| Dnase1l2tm1.1(KOMP)Wtsi | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Dnase1l2tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |