Dnase1l2 | deoxyribonuclease 1-like 2

GeneMGI:1913955Synonyms: 4733401H14Rik

Physiological systems

23 / 24 physiological systems tested

15 Significantly impacted by the knock-out

Immune system Integument Adipose tissue Growth/size/body region Digestive/alimentary Hematopoietic system Cardiovascular system Craniofacial Homeostasis/metabolism Pigmentation Limbs/digits/tail Nervous system Vision/eye Behavior/neurological Skeleton

8 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:48Significant phenotypes

0Associated diseases

Expression examined in:158Adult tissues

58Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:

Life Stage:



decreased body length	7 supporting datasets	Dnase1l2^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	7.91x10^-16
decreased grip strength	17 supporting datasets	Dnase1l2^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	1.46x10^-17
decreased locomotor activity	9 supporting datasets	Dnase1l2^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	3.35x10^-6
abnormal autopod morphology	2 supporting datasets	Dnase1l2^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	6.02x10^-5
abnormal bone structure	1 supporting dataset	Dnase1l2^{tm1(KOMP)Wtsi}	homozygote	Early adult	8.59x10^-8
abnormal digit morphology	18 supporting datasets	Dnase1l2^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	1.37x10^-19
abnormal digit morphology	3 supporting datasets	Dnase1l2^{tm1(KOMP)Wtsi}	homozygote	Early adult	2.45x10^-10
abnormal optic disk morphology	2 supporting datasets	Dnase1l2^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	6.64x10^-6
persistence of hyaloid vascular system	2 supporting datasets	Dnase1l2^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	1.08x10^-5
abnormal nail morphology	2 supporting datasets	Dnase1l2^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	5.66x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dnase1l2.

Associated images

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Histopathology

There is no histopathology data found for Dnase1l2.

IMPC related publications

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External links

No external links available for Dnase1l2.

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*Dnase1l2^em1(IMPC)Bay*	Exon Deletion	‌	mouse
*Dnase1l2^em1(IMPC)J*	Exon Deletion	‌	mouse
*Dnase1l2^em2(IMPC)Mbp*	Insertion, Intragenic deletion	‌	mouse
*Dnase1l2^{tm1(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell mouse
*Dnase1l2^{tm1.1(KOMP)Wtsi}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Dnase1l2^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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