Snrnp27 | small nuclear ribonucleoprotein 27 (U4/U6.U5)
Physiological systems
21 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Digestive/alimentary Vision/eye Behavior/neurological Mortality/aging
17 No significant impact
3 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:49Adult tissues
0Embryo tissues
| abnormal esophagus morphology | 1 supporting dataset | Snrnp27tm1b(EUCOMM)Wtsi | heterozygote | Early adult | N/A * | ||
| abnormal retina morphology | 1 supporting dataset | Snrnp27tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 3.35x10-5 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Snrnp27tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Snrnp27tm1b(EUCOMM)Wtsi | homozygote | E9.5 | N/A * | ||
| hyperactivity | 2 supporting datasets | Snrnp27tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 3.3x10-8 | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Snrnp27tm1b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
Human diseases caused by Snrnp27 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Snrnp27.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Snrnp27tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Snrnp27tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Snrnp27tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |