Sar1b | secretion associated Ras related GTPase 1B
Physiological systems
20 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Integument Hematopoietic system Skeleton Mortality/aging
15 No significant impact
4 Not tested
Data collections
Gene metrics:13Significant phenotypes
2Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| decreased circulating LDL cholesterol level | 1 supporting dataset | Sar1btm1a(EUCOMM)Wtsi | heterozygote | Early adult | 2.93x10-7 | ||
| decreased circulating cholesterol level | 1 supporting dataset | Sar1btm1a(EUCOMM)Wtsi | heterozygote | Early adult | 3.4x10-8 | ||
| decreased circulating HDL cholesterol level | 1 supporting dataset | Sar1btm1a(EUCOMM)Wtsi | heterozygote | Early adult | 4.32x10-8 | ||
| thrombocytosis | 1 supporting dataset | Sar1btm1a(EUCOMM)Wtsi | heterozygote | Early adult | 8.28x10-7 | ||
| decreased circulating serum albumin level | 1 supporting dataset | Sar1btm1a(EUCOMM)Wtsi | heterozygote | Early adult | 6.42x10-5 | ||
| decreased circulating aspartate transaminase level | 1 supporting dataset | Sar1btm1a(EUCOMM)Wtsi | heterozygote | Early adult | 1.78x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Sar1btm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased bone mineral density | 1 supporting dataset | Sar1btm1a(EUCOMM)Wtsi | heterozygote | Early adult | 9.44x10-5 | ||
| decreased circulating alanine transaminase level | 1 supporting dataset | Sar1btm1a(EUCOMM)Wtsi | heterozygote | Early adult | 9.26x10-5 | ||
| abnormal skin condition | 1 supporting dataset | Sar1btm1a(EUCOMM)Wtsi | heterozygote | Early adult | 3.64x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 100% (2/2) | 0% (0/173) |
| bone | heterozygote | n/a | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Sar1b mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Sar1b.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Sar1btm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Sar1btm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Sar1btm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |