Sar1b | secretion associated Ras related GTPase 1B

GeneMGI:1913647Synonyms: Sara2, 2900019I22Rik, +1 more

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Integument Hematopoietic system Skeleton Mortality/aging

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

2Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased circulating LDL cholesterol level	1 supporting dataset	Sar1b^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.93x10^-7
decreased circulating cholesterol level	1 supporting dataset	Sar1b^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	3.4x10^-8
decreased circulating HDL cholesterol level	1 supporting dataset	Sar1b^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	4.32x10^-8
thrombocytosis	1 supporting dataset	Sar1b^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	8.28x10^-7
decreased circulating serum albumin level	1 supporting dataset	Sar1b^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	6.42x10^-5
decreased circulating aspartate transaminase level	1 supporting dataset	Sar1b^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.78x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Sar1b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased bone mineral density	1 supporting dataset	Sar1b^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	9.44x10^-5
decreased circulating alanine transaminase level	1 supporting dataset	Sar1b^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	9.26x10^-5
abnormal skin condition	1 supporting dataset	Sar1b^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	3.64x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Sar1b.

Associated images

Loading...

Histopathology

There is no histopathology data found for Sar1b.

IMPC related publications

Loading...

External links

No external links available for Sar1b.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Sar1b^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Sar1b^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Sar1b^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

My Genes