Sar1b | secretion associated Ras related GTPase 1B

GeneMGI:1913647Synonyms: Sara2, 2900019I22Rik, +1 more

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Integument Hematopoietic system Skeleton Mortality/aging

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

2Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased circulating LDL cholesterol level	1 supporting dataset	Sar1b^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.93x10^-7
decreased circulating cholesterol level	1 supporting dataset	Sar1b^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	3.4x10^-8
decreased circulating HDL cholesterol level	1 supporting dataset	Sar1b^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	4.32x10^-8
thrombocytosis	1 supporting dataset	Sar1b^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	8.28x10^-7
decreased circulating serum albumin level	1 supporting dataset	Sar1b^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	6.42x10^-5
decreased circulating aspartate transaminase level	1 supporting dataset	Sar1b^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.78x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Sar1b^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased bone mineral density	1 supporting dataset	Sar1b^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	9.44x10^-5
decreased circulating alanine transaminase level	1 supporting dataset	Sar1b^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	9.26x10^-5
abnormal skin condition	1 supporting dataset	Sar1b^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	3.64x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sar1b.

Associated images

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Histopathology

There is no histopathology data found for Sar1b.

IMPC related publications

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External links

No external links available for Sar1b.

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*Sar1b^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Sar1b^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Sar1b^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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