Atp6v1c1 | ATPase, H+ transporting, lysosomal V1 subunit C1
Physiological systems
19 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Immune system Nervous system Hematopoietic system Behavior/neurological Mortality/aging
14 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
30Embryo tissues
| increased mean corpuscular volume | 1 supporting dataset | Atp6v1c1tm1b(NCOM)Mfgc | heterozygote | Early adult | 3.86x10-9 | ||
| increased leukocyte cell number | 1 supporting dataset | Atp6v1c1tm1b(NCOM)Mfgc | heterozygote | Early adult | 5.08x10-5 | ||
| decreased prepulse inhibition | 4 supporting datasets | Atp6v1c1tm1b(NCOM)Mfgc | heterozygote | Early adult | 9.5x10-12 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Atp6v1c1tm1b(NCOM)Mfgc | homozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Atp6v1c1tm1b(NCOM)Mfgc | homozygote | Early adult | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Atp6v1c1tm1b(NCOM)Mfgc | homozygote | E12.5 | N/A * | ||
| decreased exploration in new environment | 1 supporting dataset | Atp6v1c1tm1b(NCOM)Mfgc | heterozygote | Early adult | 2.61x10-6 |
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Human diseases caused by Atp6v1c1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Atp6v1c1.
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| Atp6v1c1tm1a(NCOM)Mfgc | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Atp6v1c1tm1b(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | mouse |