Gkn2 | gastrokine 2
Physiological systems
21 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Growth/size/body region Limbs/digits/tail Nervous system Hematopoietic system Cardiovascular system
14 No significant impact
3 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| decreased fasting circulating glucose level | 1 supporting dataset | Gkn2tm1.1(KOMP)Vlcg | homozygote | Early adult | 8.29x10-5 | ||
| brachydactyly | 1 supporting dataset | Gkn2tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.26x10-6 | ||
| decreased brain weight | 1 supporting dataset | Gkn2tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.86x10-7 | ||
| decreased total body fat amount | 1 supporting dataset | Gkn2tm1.1(KOMP)Vlcg | homozygote | Early adult | 2.26x10-5 | ||
| increased lean body mass | 1 supporting dataset | Gkn2tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.88x10-5 | ||
| enlarged heart | 1 supporting dataset | Gkn2tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| decreased mean corpuscular volume | 1 supporting dataset | Gkn2tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.5x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/4) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/4) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 0% (0/4) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/4) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 50% (2/4) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/4) | 0.56% (3/532) |
Human diseases caused by Gkn2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Gkn2.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Gkn2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Gkn2tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Gkn2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Gkn2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Gkn2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Gkn2tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |