Med11 | mediator complex subunit 11

GeneMGI:1913422Synonyms: 1110030J09Rik

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Limbs/digits/tail Mortality/aging

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

1Associated diseases

Expression examined in:49Adult tissues

25Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



embryonic lethality prior to tooth bud stage	1 supporting dataset	Med11^{tm1.1(KOMP)Vlcg}	homozygote	E12.5	N/A ^*
increased fasting circulating glucose level	1 supporting dataset	Med11^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	1.06x10^-5
abnormal tail bud morphology	1 supporting dataset	Med11^{tm1.1(KOMP)Vlcg}	homozygote	E9.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Med11^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
decreased circulating glucose level	1 supporting dataset	Med11^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	6.91x10^-5
decreased circulating calcium level	1 supporting dataset	Med11^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	4.5x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Med11.

Associated images

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Histopathology

There is no histopathology data found for Med11.

IMPC related publications

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External links

No external links available for Med11.

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*Med11^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Med11^{tm1(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Med11^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Med11^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Med11^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Med11^{tm438123(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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