Ska2 | spindle and kinetochore associated complex subunit 2

GeneMGI:1913390Synonyms: 1110001A07Rik, Fam33a

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system Behavior/neurological Mortality/aging

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

25Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



increased circulating bilirubin level	1 supporting dataset	Ska2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.24x10^-9
thrombocytopenia	1 supporting dataset	Ska2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	7.08x10^-5
increased circulating HDL cholesterol level	1 supporting dataset	Ska2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	6.88x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Ska2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.46x10^-20
increased circulating alanine transaminase level	1 supporting dataset	Ska2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.89x10^-6
hyperactivity	1 supporting dataset	Ska2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	5.96x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Ska2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Ska2^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
decreased circulating free fatty acids level	1 supporting dataset	Ska2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.65x10^-5
decreased circulating triglyceride level	1 supporting dataset	Ska2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.86x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ska2.

Associated images

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Histopathology

There is no histopathology data found for Ska2.

IMPC related publications

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External links

No external links available for Ska2.

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*Ska2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ska2^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ska2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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