Elof1 | ELF1 homolog, elongation factor 1
Physiological systems
20 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Behavior/neurological Cardiovascular system Mortality/aging
15 No significant impact
4 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:49Adult tissues
25Embryo tissues
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Elof1tm1.1(KOMP)Vlcg | homozygote | E12.5 | N/A * | ||
| decreased coping response | 2 supporting datasets | Elof1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 9.55x10-6 | ||
| decreased circulating serum albumin level | 1 supporting dataset | Elof1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 4.96x10-6 | ||
| increased heart weight | 1 supporting dataset | Elof1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 9x10-5 | ||
| increased circulating sodium level | 1 supporting dataset | Elof1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 8.44x10-7 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Elof1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * |
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| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| bone marrow | heterozygote | Section images | 100% (2/2) | 0% (0/22) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
Human diseases caused by Elof1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Elof1.
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| Elof1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Elof1tm1(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Elof1tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Elof1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |