Tomm6 | translocase of outer mitochondrial membrane 6

GeneMGI:1913369Synonyms: 1110002E23Rik

Physiological systems

23 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Endocrine/exocrine gland Growth/size/body region Digestive/alimentary Behavior/neurological Cardiovascular system Mortality/aging

15 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:78Adult tissues

27Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



enlarged heart	1 supporting dataset	Tomm6^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*
abnormal salivary gland morphology	1 supporting dataset	Tomm6^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*
increased circulating lactate dehydrogenase level	1 supporting dataset	Tomm6^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	3.3x10^-7
preweaning lethality, incomplete penetrance	1 supporting dataset	Tomm6^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal heart morphology	1 supporting dataset	Tomm6^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*
abnormal lymph node morphology	1 supporting dataset	Tomm6^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*
enlarged lymph nodes	1 supporting dataset	Tomm6^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*
no spontaneous movement	1 supporting dataset	Tomm6^{tm1a(KOMP)Wtsi}	homozygote	E18.5	N/A ^*
increased circulating aspartate transaminase level	1 supporting dataset	Tomm6^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	1.69x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tomm6.

Associated images

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Histopathology

There is no histopathology data found for Tomm6.

IMPC related publications

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External links

No external links available for Tomm6.

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*Tomm6^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Tomm6^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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