Emc3 | ER membrane protein complex subunit 3

GeneMGI:1913337Synonyms: Tmem111, 0610039A15Rik

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Adipose tissue Growth/size/body region Behavior/neurological Skeleton Mortality/aging

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased bone mineral content1 supporting datasetEmc3tm1b(EUCOMM)WtsiheterozygoteEarly adult1.48x10-5 
preweaning lethality, complete penetrance1 supporting datasetEmc3tm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
increased total body fat amount1 supporting datasetEmc3tm1b(EUCOMM)WtsiheterozygoteEarly adult1.59x10-5 
decreased vertical activity1 supporting datasetEmc3tm1b(EUCOMM)WtsiheterozygoteEarly adult1.51x10-5 
decreased lean body mass1 supporting datasetEmc3tm1b(EUCOMM)WtsiheterozygoteEarly adult3.89x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Emc3tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Emc3tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Emc3tm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Emc3tm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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