Eif3f | eukaryotic translation initiation factor 3, subunit F

GeneMGI:1913335Synonyms: 0610037M02Rik, Eif3s5

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Pigmentation Integument Mortality/aging

16 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:2Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal coat/hair pigmentation1 supporting datasetEif3fem1(IMPC)HmguheterozygoteEarly adult4.68x10-10 
preweaning lethality, complete penetrance1 supporting datasetEif3fem1(IMPC)HmguhomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Human diseases caused by Eif3f mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.






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Histopathology

IMPC related publications

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Eif3fem1(IMPC)HmguExon Deletionmouse
Eif3ftm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Eif3ftm44424(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Eif3ftm44424(L1L2_gt1)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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