Cldn13 | claudin 13
Physiological systems
18 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Pigmentation Integument Vision/eye Hematopoietic system Behavior/neurological
12 No significant impact
6 Not tested
Data collections
Gene metrics:12Significant phenotypes
0Associated diseases
Expression examined in:49Adult tissues
46Embryo tissues
| abnormal startle reflex | 1 supporting dataset | Cldn13em1(IMPC)J | homozygote | Late adult | 5.15x10-5 | ||
| increased circulating potassium level | 1 supporting dataset | Cldn13tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.09x10-5 | ||
| increased hemoglobin content | 1 supporting dataset | Cldn13tm1.1(KOMP)Vlcg | homozygote | Early adult | 6.51x10-5 | ||
| decreased mean corpuscular volume | 1 supporting dataset | Cldn13tm1.1(KOMP)Vlcg | homozygote | Early adult | 9.27x10-6 | ||
| increased circulating sodium level | 1 supporting dataset | Cldn13tm1.1(KOMP)Vlcg | homozygote | Early adult | 2.95x10-5 | ||
| decreased grip strength | 1 supporting dataset | Cldn13em1(IMPC)J | homozygote | Early adult | 2.3x10-5 | ||
| abnormal coat/hair pigmentation | 6 supporting datasets | Cldn13em1(IMPC)J | homozygote | Late adult | 8.43x10-11 | ||
| persistence of hyaloid vascular system | 1 supporting dataset | Cldn13em1(IMPC)J | homozygote | Early adult | 1.51x10-5 | ||
| increased erythrocyte cell number | 1 supporting dataset | Cldn13tm1.1(KOMP)Vlcg | homozygote | Early adult | 2.56x10-7 | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Cldn13em1(IMPC)J | homozygote | Late adult | 7.21x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 50% (1/2) | 0.19% (1/533) |
| bone marrow | heterozygote | Section images | 100% (2/2) | 0% (0/22) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | n/a | 0% (0/1) | 87.5% (21/24) |
Human diseases caused by Cldn13 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Cldn13.
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| Cldn13em1(IMPC)J | Indel | | mouse |
| Cldn13tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Cldn13tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Cldn13tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Cldn13tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Cldn13tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Cldn13tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |