Ywhab | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide

GeneMGI:1891917Synonyms: 14-3-3b, 14-3-3 beta, +1 more

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Hematopoietic system Behavior/neurological

16 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal retina morphology	1 supporting dataset	Ywhab^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.12x10^-18
decreased circulating iron level	1 supporting dataset	Ywhab^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.96x10^-5
decreased circulating total protein level	1 supporting dataset	Ywhab^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.1x10^-6
decreased blood urea nitrogen level	1 supporting dataset	Ywhab^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.24x10^-6
decreased total retina thickness	2 supporting datasets	Ywhab^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.7x10^-21
abnormal behavior	1 supporting dataset	Ywhab^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.76x10^-5
thrombocytopenia	1 supporting dataset	Ywhab^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.18x10^-7
decreased circulating triglyceride level	1 supporting dataset	Ywhab^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.62x10^-5
decreased circulating cholesterol level	1 supporting dataset	Ywhab^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.45x10^-7
increased circulating bilirubin level	1 supporting dataset	Ywhab^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.56x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ywhab.

Associated images

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Histopathology

There is no histopathology data found for Ywhab.

IMPC related publications

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External links

No external links available for Ywhab.

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*Ywhab^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Ywhab^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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