Plag1 | pleiomorphic adenoma gene 1

GeneMGI:1891916

Physiological systems

20 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Limbs/digits/tail Hearing/vestibular/ear Hematopoietic system Behavior/neurological Skeleton Craniofacial

11 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal snout morphology	1 supporting dataset	Plag1^{em1(IMPC)Hmgu}	homozygote	Early adult	1.29x10^-17
abnormal head morphology	1 supporting dataset	Plag1^{em1(IMPC)Hmgu}	homozygote	Early adult	6.78x10^-21
short tibia	1 supporting dataset	Plag1^{em1(IMPC)Hmgu}	homozygote	Early adult	1.76x10^-18
increased grip strength	1 supporting dataset	Plag1^{em1(IMPC)Hmgu}	homozygote	Early adult	1.73x10^-5
abnormal auditory brainstem response	1 supporting dataset	Plag1^{em1(IMPC)Hmgu}	homozygote	Early adult	2.61x10^-5
decreased startle reflex	1 supporting dataset	Plag1^{em1(IMPC)Hmgu}	homozygote	Early adult	1.02x10^-6
increased circulating aspartate transaminase level	1 supporting dataset	Plag1^{em1(IMPC)Hmgu}	homozygote	Early adult	1.69x10^-5
decreased CD8-positive, naive alpha-beta T cell number	1 supporting dataset	Plag1^{em1(IMPC)Hmgu}	homozygote	Early adult	4.74x10^-5
increased red blood cell distribution width	1 supporting dataset	Plag1^{em1(IMPC)Hmgu}	homozygote	Early adult	4.28x10^-6
decreased body length	1 supporting dataset	Plag1^{em1(IMPC)Hmgu}	homozygote	Early adult	8.44x10^-9

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Plag1.

Associated images

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Histopathology

There is no histopathology data found for Plag1.

IMPC related publications

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External links

No external links available for Plag1.

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*Plag1^{em1(IMPC)Hmgu}*	Exon Deletion	‌	mouse
*Plag1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Plag1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Plag1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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