Becn1 | beclin 1, autophagy related

GeneMGI:1891828Synonyms: Atg6

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Mortality/aging

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased lean body mass	2 supporting datasets	Becn1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	4.4x10^-7
increased circulating bilirubin level	1 supporting dataset	Becn1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.06x10^-5
increased total body fat amount	2 supporting datasets	Becn1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	8.5x10^-8
decreased circulating HDL cholesterol level	1 supporting dataset	Becn1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	4.01x10^-5
increased startle reflex	1 supporting dataset	Becn1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	4.58x10^-10
preweaning lethality, complete penetrance	1 supporting dataset	Becn1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased leukocyte cell number	1 supporting dataset	Becn1^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	3.96x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Becn1.

Associated images

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Histopathology

There is no histopathology data found for Becn1.

IMPC related publications

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External links

No external links available for Becn1.

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*Becn1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Becn1^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Becn1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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