Hbs1l | Hbs1-like (S. cerevisiae)
Physiological systems
18 / 24 physiological systems tested
10 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Adipose tissue Growth/size/body region Limbs/digits/tail Vision/eye Hematopoietic system Skeleton Craniofacial
8 No significant impact
6 Not tested
Data collections
Gene metrics:33Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased regulatory T cell number | 4 supporting datasets | Hbs1ltm1a(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| increased circulating iron level | 1 supporting dataset | Hbs1ltm1a(KOMP)Wtsi | homozygote | Early adult | 2.8x10-6 | ||
| decreased effector memory CD8-positive, alpha-beta T cell number | 3 supporting datasets | Hbs1ltm1a(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| increased circulating total protein level | 1 supporting dataset | Hbs1ltm1a(KOMP)Wtsi | homozygote | Early adult | 8.47x10-7 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Hbs1ltm1a(KOMP)Wtsi | homozygote | Early adult | 7.63x10-5 | ||
| increased CD4-positive, alpha-beta memory T cell number | 4 supporting datasets | Hbs1ltm1a(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| cornea opacity | 1 supporting dataset | Hbs1ltm1a(KOMP)Wtsi | homozygote | Early adult | 6.25x10-5 | ||
| decreased monocyte cell number | 1 supporting dataset | Hbs1ltm1a(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| vertebral transformation | 1 supporting dataset | Hbs1ltm1a(KOMP)Wtsi | homozygote | Early adult | 7.17x10-5 | ||
| decreased Langerhans cell number | 1 supporting dataset | Hbs1ltm1a(KOMP)Wtsi | homozygote | Early adult | N/A * |
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Human diseases caused by Hbs1l mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Hbs1l.
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| Hbs1ltm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Hbs1ltm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |