Hbs1l | Hbs1-like (S. cerevisiae)

GeneMGI:1891704Synonyms: 2810035F15Rik, eRFS

Physiological systems

18 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Adipose tissue Growth/size/body region Limbs/digits/tail Vision/eye Hematopoietic system Skeleton Craniofacial

8 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:33Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased regulatory T cell number	4 supporting datasets	Hbs1l^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating iron level	1 supporting dataset	Hbs1l^{tm1a(KOMP)Wtsi}	homozygote	Early adult	2.8x10^-6
decreased effector memory CD8-positive, alpha-beta T cell number	3 supporting datasets	Hbs1l^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating total protein level	1 supporting dataset	Hbs1l^{tm1a(KOMP)Wtsi}	homozygote	Early adult	8.47x10^-7
increased circulating alkaline phosphatase level	1 supporting dataset	Hbs1l^{tm1a(KOMP)Wtsi}	homozygote	Early adult	7.63x10^-5
increased CD4-positive, alpha-beta memory T cell number	4 supporting datasets	Hbs1l^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
cornea opacity	1 supporting dataset	Hbs1l^{tm1a(KOMP)Wtsi}	homozygote	Early adult	6.25x10^-5
decreased monocyte cell number	1 supporting dataset	Hbs1l^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
vertebral transformation	1 supporting dataset	Hbs1l^{tm1a(KOMP)Wtsi}	homozygote	Early adult	7.17x10^-5
decreased Langerhans cell number	1 supporting dataset	Hbs1l^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Hbs1l.

Associated images

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Histopathology

There is no histopathology data found for Hbs1l.

IMPC related publications

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External links

No external links available for Hbs1l.

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*Hbs1l^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Hbs1l^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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