Pnkp | polynucleotide kinase 3'- phosphatase

GeneMGI:1891698Synonyms: PNK, 1810009G08Rik

Physiological systems

21 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Integument Growth/size/body region Vision/eye Mortality/aging Renal/urinary system

16 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

6Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, complete penetrance	3 supporting datasets	Pnkp^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
enlarged kidney	1 supporting dataset	Pnkp^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Pnkp^em1(IMPC)Mbp	homozygote	E9.5	N/A ^*
microphthalmia	1 supporting dataset	Pnkp^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Pnkp^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
single kidney	1 supporting dataset	Pnkp^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal eye morphology	1 supporting dataset	Pnkp^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal skin morphology	1 supporting dataset	Pnkp^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pnkp.

Associated images

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Histopathology

There is no histopathology data found for Pnkp.

IMPC related publications

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External links

No external links available for Pnkp.

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*Pnkp^em1(IMPC)Mbp*	Inter-exon deletion	‌	mouse
*Pnkp^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Pnkp^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Pnkp^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Pnkp^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Pnkp^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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