Pnkp | polynucleotide kinase 3'- phosphatase
Physiological systems
21 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Integument Growth/size/body region Vision/eye Mortality/aging Renal/urinary system
16 No significant impact
3 Not tested
Data collections
Gene metrics:8Significant phenotypes
6Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 3 supporting datasets | Pnkpem1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| enlarged kidney | 1 supporting dataset | Pnkpem1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Pnkpem1(IMPC)Mbp | homozygote | E9.5 | N/A * | ||
| microphthalmia | 1 supporting dataset | Pnkpem1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| abnormal kidney morphology | 1 supporting dataset | Pnkpem1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| single kidney | 1 supporting dataset | Pnkpem1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| abnormal eye morphology | 1 supporting dataset | Pnkpem1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| abnormal skin morphology | 1 supporting dataset | Pnkpem1(IMPC)Mbp | heterozygote | Early adult | N/A * |
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Human diseases caused by Pnkp mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Pnkp.
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| Pnkpem1(IMPC)Mbp | Inter-exon deletion | | mouse |
| Pnkptm1(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Pnkptm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Pnkptm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Pnkptm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Pnkptm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |